Kikuube District is located in the mid-western region of Uganda, with Kikuube Town Council the seat of the District Headquarters around 230 km from Kampala using the direct Kampala – Kiboga – Hoima – Kikuube road. It shares boarders with Hoima Districts in the North, Kyankwazi District in the East, Kagadi, Kakumiro, and Ntoroko Districts in the South. The District stretches to the national boundary of the Democratic Republic of Congo in the Western.